Matthew E. Levison, MD
Aminoglycosides are commonly used because of their broad-spectrum and reliable antimicrobial activity against aerobic gram-negative bacilli, with fewer than 5% of strains resistant. To explain the rationale underlying the novel proposal of single daily dosing of aminoglycosides, I will describe their pharmacodynamics—the relation of the time course of their antimicrobial effect to concentrations of the antibiotic at the site of the infection (1-6).
Administering the total daily dose of aminoglycoside once daily, rather than in divided doses, has recently been proposed to improve efficacy and possibly to reduce toxicity (7). Aminoglycosides have concentration-dependent bactericidal action; that is, larger doses can
Matthew E. Levison. New Dosing Regimens for Aminoglycoside Antibiotics. Ann Intern Med. 1992;117:693–694. doi: 10.7326/0003-4819-117-8-693
Download citation file:
Published: Ann Intern Med. 1992;117(8):693-694.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use