Michele G. Cyr, MD; Anne W. Moulton, MD; Michael D. Stein, MD
To the Editors: Suh and colleagues (1) report results from the Multiple Risk Factor Intervention Trial (MRFIT) suggesting that for light- to moderate-drinking middle-aged men, the inverse association between alcohol consumption and coronary heart disease mortality can be explained largely by increased high-density lipoprotein (HDL) levels. What is not stated explicitly is that these results should not be generalized from middle-aged men to women.
Women differ from men, particularly concerning alcohol. What is considered light to moderate drinking for men is potentially hazardous for women. More specifically, the risk for alcohol-related morbidity begins to increase significantly at alcohol consumption above
Cyr MG, Moulton AW, Stein MD. MRFIT, "MS FIT," and Alcohol Use. Ann Intern Med. ;117:874–875. doi: 10.7326/0003-4819-117-10-874
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Published: Ann Intern Med. 1992;117(10):874-875.
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