Raymond S. Koff, MD
Hepatitis C virus (HCV) is a hot topic. Because the literature is constantly expanding, keeping current with new research is no simple task for either the clinician or investigator. The "big bang" of HCV research is readily traced to the brilliant efforts and perseverance of Houghton and colleagues who, working collaboratively with Bradley, cloned the HCV genome (1). This remarkable achievement permitted a proliferation of specific assays to study HCV infection. The humoral immune response to HCV was assessed initially by radioimmunoassay, but the development of first-generation enzyme-linked immunosorbent assays (ELISAs) and recombinant immunoblot assays (RIBAs) and then second-generation assays
Koff RS. The Low Efficiency of Maternal-Neonatal Transmission of Hepatitis C Virus: How Certain Are We?. Ann Intern Med. ;117:967–969. doi: 10.7326/0003-4819-117-11-967
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Published: Ann Intern Med. 1992;117(11):967-969.
Gastroenterology/Hepatology, Infectious Disease, Viral Hepatitis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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