Shunichi Yamashita, MD; Motomori Izumi, MD; Shigenobu Nagataki, MD
To the Editors: Growth hormone (GH)-secreting adenocarcinoma with clear evidence of distant metastasis has been unequivocally documented in only five patients (1, 2).
We report the case of an acromegalic patient with pituitary adenocarcinoma and elevated levels of circulating GH (80 μg/L) and insulin-like growth factor (IGF)-I (10 U/mL) as well as spinal cord metastasis.
A 35-year-old Japanese woman was referred for further management of a previously diagnosed pituitary adenoma. She had been treated surgically at 19 and 31 years of age and with radiation at 33 and 34 years of age. Previous computed tomography showed a pituitary tumor, histologically
Yamashita S, Izumi M, Nagataki S. Acromegaly and Pituitary Carcinoma. Ann Intern Med. 1992;117:1057–1058. doi: 10.7326/0003-4819-117-12-1057
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Published: Ann Intern Med. 1992;117(12):1057-1058.
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