Patrick E. Olson, MD; Charles A. Kennedy, MD; Paul D. Morte, MD
To the Editors: Central neurologic side effects of mefloquine have been described previously (1-5), but to our knowledge peripheral nervous system toxicity has not. We report a case of paresthesias and painful dysesthesias associated with mefloquine chemoprophylaxis.
A previously healthy, 45-year-old, white, male oral surgeon presented in preparation for a 2-week trip to rural Kenya. Mefloquine (Lariam, Roche Laboratories, Nutley, New Jersey), 250 mg weekly, was prescribed. Treatment was to begin the week before departure and to continue through 4 weeks after return.
On returning from Africa (week 3 of treatment), the patient noted a transient (30- to 45-minute) episode
Olson PE, Kennedy CA, Morte PD. Paresthesias and Mefloquine Prophylaxis. Ann Intern Med. ;117:1058–1059. doi: 10.7326/0003-4819-117-12-1058_2
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Published: Ann Intern Med. 1992;117(12):1058-1059.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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