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Letters |15 February 1993

Microalbuminuria, Lipoproteins, and Diabetic Control

Connie L. Manske, MD

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TO THE EDITOR:
Ramirez and colleagues [1] have shown a relation between high Lp(a) levels and poor glycemic control in diabetic patients. They did not, however, include data on a major potential confounding factor—urinary protein excretion. Several investigators have documented a dramatic increase in Lp(a) levels in nondiabetic patients with heavy proteinuria as well as in diabetic patients with microalbuminuria [2-4]. Because the presence of diabetic nephropathy correlates with poor glycemic control [5], proteinuria was probably more prevalent in the patients with HbA1c levels greater than 8%. Does the association of poor glycemic control and high Lp(a) levels persist after controlling for elevated urinary protein excretion?
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Manske CL. Microalbuminuria, Lipoproteins, and Diabetic Control. Ann Intern Med. 1993;118:312–313. doi: 10.7326/0003-4819-118-4-199302150-00014

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Published: Ann Intern Med. 1993;118(4):312-313.

DOI: 10.7326/0003-4819-118-4-199302150-00014

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