David B. Badesch, MD; Kristine M. Wynne, RN, BSN; Scott Bonvallet, MD; Norbert F. Voelkel, MD; Chester Ridgway, MD; Bertron M. Groves, MD
Primary pulmonary hypertension (PPH), an often fatal disease of unknown cause that primarily affects young women, is a diagnosis of exclusion. The relative roles of genetic predisposition, autoimmunity, viral infection, hormonal influences, and environmental and drug exposures are not known. Among seven patients enrolled by our center in a multicenter trial of continuous prostacyclin in severe PPH, four of the five women had hypothyroidism. Although a causal relationship cannot be established based on this small case series, the possibility of an autoimmune pathogenetic link between PPH and hypothyroidism should be investigated further.
Badesch DB, Wynne KM, Bonvallet S, Voelkel NF, Ridgway C, Groves BM. Hypothyroidism and Primary Pulmonary Hypertension: An Autoimmune Pathogenetic Link?. Ann Intern Med. ;119:44–46. doi: 10.7326/0003-4819-119-1-199307010-00008
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Published: Ann Intern Med. 1993;119(1):44-46.
Endocrine and Metabolism, Pulmonary Hypertension, Pulmonary/Critical Care, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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