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Letters |15 November 1993

Effect of Inhaled Steroids on the Course of Asthma

Constance P. van Schayck, MD; Edward Dompeling, MD; Hans Folgering, MD

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To determine whether inhaled corticosteroid treatment prevents the accelerated decline in FEV1 observed during bronchodilator therapy alone, patients must be observed during a prolonged bronchodilator treatment period with and without inhaled steroids. This was not done in the study by Kerstjens and colleagues [1], a randomized, controlled trial of bronchodilator therapy with or without inhaled corticosteroids. Kerstjens and associates reported that patients who used only the 2-agonist had an FEV1 decline of 64 mL per year and that the patients who used the combination of the 2-agonist and the inhaled steroid had an FEV1 decline of 33 mL per year. It would have been interesting to follow the patients who received the 2-agonist alone after the addition of an inhaled steroid.
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van Schayck CP, Dompeling E, Folgering H. Effect of Inhaled Steroids on the Course of Asthma. Ann Intern Med. ;119:1051–1052. doi: 10.7326/0003-4819-119-10-199311150-00023

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Published: Ann Intern Med. 1993;119(10):1051-1052.

DOI: 10.7326/0003-4819-119-10-199311150-00023

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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