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Editorials |15 December 1993

Hemlock or Healer? The Mercurial Reputation of Theophylline

Paul E. Epstein, MD

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Author, Article, and Disclosure Information
Copyright 2004 by the American College of Physicians
2004
  • Graduate Hospital, Philadelphia, PA 19146. Requests for Reprints: Paul E. Epstein, MD, Pulmonary Division, Graduate Hospital, 607 Pepper Pavilion, 18th and Lombard Streets, Philadelphia, PA 19146.
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In this issue of Annals, two articles [1, 2] discuss facets of theophylline administration that recall a hoary clinical dilemma: Is the drug useful enough to justify the danger of serious toxicity and, if so, how should it be used?
In the first article, Huang and coworkers [1] describe a carefully performed double-blind, placebo-controlled study that shows convincingly that during the first 48 hours after hospitalization for asthma, theophylline, when added to albuterol and methylprednisolone, produces more rapid and sustained improvement in airflow rates than the same regimen lacking theophylline.
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Epstein PE. Hemlock or Healer? The Mercurial Reputation of Theophylline. Ann Intern Med. 1993;119:1216–1217. doi: 10.7326/0003-4819-119-12-199312150-00010

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Published: Ann Intern Med. 1993;119(12):1216-1217.

DOI: 10.7326/0003-4819-119-12-199312150-00010

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