Gloria Gridley, MS; John H. Klippel, MD; Robert N. Hoover, MD; Joseph F. Fraumeni Jr., MD
To estimate the incidence of cancer (especially lymphoproliferative malignancies) in patients with the Felty syndrome.
A retrospective cohort study.
A computerized database of all discharge records for 1969 to 1990 from a Veterans Affairs hospital.
906 men with a discharge diagnosis of the Felty syndrome.
Standardized incidence ratios (SIR) (ratios of observed-to-expected events) estimated the risk for specific cancers. Hospital records confirmed the diagnoses of the Felty syndrome and cancer.
We observed a twofold increase in total cancer incidence (137 patients; SIR = 2.09; 95% CI, 1.8 to 2.5). The risk for non-Hodgkin lymphoma (19 patients; SIR = 12.8, CI, 7.7 to 20.0) was much greater than the twofold increase in risk for lymphoma generally reported for rheumatoid arthritis. The risk for leukemia was increased but only within 5 years of the first hospitalization for the Felty syndrome, (13 patients; SIR = 7.67; CI, 4.1 to 13.1).
The increased risk for non-Hodgkin lymphoma after the Felty syndrome in our study is similar to the risk associated with the Sjogren syndrome and may reflect similar immunostimulatory mechanisms.
Gridley G, Klippel JH, Hoover RN, Fraumeni JF. Incidence of Cancer among Men with the Felty Syndrome. Ann Intern Med. 1994;120:35–39. doi: 10.7326/0003-4819-120-1-199401010-00006
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Published: Ann Intern Med. 1994;120(1):35-39.
Hematology/Oncology, Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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