Skip Navigation
Menu
Letters |1 March 1994

Special Problems in Treating Tuberculosis

Nadim Salomon, MD; David C. Perlman, MD; Susan Goldstein, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Beth Israel Medical Center; New York, NY 10003
×
FULL TEXT
TO THE EDITOR:
Barnes and Barrows [1] suggest that a regimen of ethambutol, ofloxacin, and an aminoglycoside can be used when antituberculous medication-induced hepatotoxicity occurs. We have recently reviewed our experience with this approach in 14 patients infected with the human immunodeficiency virus (HIV) (median CD4+ cell count, 39 cells/mm3) who had developed symptomatic liver disease while receiving regimens containing isoniazid, rifampin, and pyrazinamide for active tuberculosis [2]. In 13 patients (93%), liver test abnormalities occurred within the first 2 months of treatment. All had severe hepatotoxicity manifested by abdominal pain (71%), vomiting (50%), jaundice (57%), and encephalopathy (21%), with mean elevations of the aspartate aminotransferase and total bilirubin levels to 9.2 and 6.2 times the upper limits of normal, respectively.
FULL TEXT
PDF
Not Available
Citations
Citation

Salomon N, Perlman DC, Goldstein S. Special Problems in Treating Tuberculosis. Ann Intern Med. 1994;120:440–441. doi: 10.7326/0003-4819-120-5-199403010-00026

Download citation file:

© 2018

×
Permissions

Published: Ann Intern Med. 1994;120(5):440-441.

DOI: 10.7326/0003-4819-120-5-199403010-00026

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2018 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×