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Letters |15 November 1994

Pseudonephrotic Syndrome Caused by Lysozymuria

C. C. Mok; S. C. F. Tam; Y. L. Kwong

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  • Queen Mary Hospital, Pokfulam, Hong Kong.
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TO THE EDITOR:
A causal link between the nephrotic syndrome and acute leukemia is extremely rare [1]. Most reviews have focused on either glomerular or tubular injury that has resulted in urinary protein leakage. Lysozymuria itself as the cause of a gross proteinuria has not been previously reported.
A 57-year-old man presented with a 2-week history of fever and bilateral ankle edema. His leukocyte count was 65 × 109/L (70% monoblasts), and examination of a bone marrow biopsy specimen confirmed the diagnosis of acute monoblastic leukemia. His urine had tested strongly positive for protein with a routine bedside strip test (Ames Co., Miles Laboratories, Australia Pty. Ltd.). Twenty-four hour urine sampling showed 5 g of protein, assayed with an end-point colorimetric method that used pyrogallol red molybdenum and read spectrophotometrically at 620 nm. His renal function and urine microscopy results were normal.
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Mok CC, Tam SCF, Kwong YL. Pseudonephrotic Syndrome Caused by Lysozymuria. Ann Intern Med. ;121:818. doi: 10.7326/0003-4819-121-10-199411150-00020

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Published: Ann Intern Med. 1994;121(10):818.

DOI: 10.7326/0003-4819-121-10-199411150-00020

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