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Letters |15 April 1995

HLA Typing in Patients with Wegener Granulomatosis

Mary Frances Cotch; Anthony S. Fauci; Gary S. Hoffman

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Author, Article, and Disclosure Information
  • Research Triangle Institute, Center for Medical, Environmental and Energy, Rockville, MD 20852. National Institutes of Health, Bethesda, MD 20892. The Cleveland Clinic Foundation, Cleveland, OH 44195.
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TO THE EDITOR:
To investigate a potential genetic basis for Wegener granulomatosis, we screened 83 patients for human leukocyte antigen (HLA) A, B, and C, and DR-DQ markers and compared the frequencies of these phenotypes with those in 4039 normal persons screened for organ donation and 2163 normal persons randomly selected for histocompatibility testing. The results of chi-square analyses showed that B50 and DR9 phenotypes were statistically more likely to occur in patients with Wegener granulomatosis. In the two control groups, the frequency for the B50 phenotype was 1.5% and 2.2%, respectively, and the frequency for the DR9 phenotype was 1.7% and 1.6%, respectively (Table 1). The B50 and DR9 phenotypes, however, occurred in only 8.4% and 6.7% of patients, respectively.
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Cotch MF, Fauci AS, Hoffman GS. HLA Typing in Patients with Wegener Granulomatosis. Ann Intern Med. 1995;122:635. doi: 10.7326/0003-4819-122-8-199504150-00029

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Published: Ann Intern Med. 1995;122(8):635.

DOI: 10.7326/0003-4819-122-8-199504150-00029

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