James A. Strauchen, MD; A. Daniel Hauser, MD; David Burstein, MD; Ricardo Jimenez, MD; Patrick S. Moore, MD; Yuan Chang, MD
The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established.
To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma.
Academic medical center.
A 94-year-old man with lymphomatous ascites.
Polymerase chain reaction (PCR) and Southern blot DNA analysis.
The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpesvirus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation.
Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.
James A. Strauchen, A. Daniel Hauser, David Burstein, Ricardo Jimenez, Patrick S. Moore, Yuan Chang. Body Cavity-Based Malignant Lymphoma Containing Kaposi Sarcoma-Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma. Ann Intern Med. 1996;125:822–825. doi: 10.7326/0003-4819-125-10-199611150-00006
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Published: Ann Intern Med. 1996;125(10):822-825.
Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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