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Letters |1 January 1997

Cyclophosphamide-Induced Bladder Cancer

Michael C. Sneller, MD; McClellan M. Walther, MD; Cheryl Talar-Williams, MPH, PAC

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  • National Institutes of Health; Bethesda, MD 20892
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Dr. Gossmann suggests that our finding of an association between nonglomerular hematuria and bladder cancer in patients receiving cyclophosphamide may be biased because we did cystoscopy only in patients with nonglomerular hematuria. Dr. Gossman does not accurately quote the literature when stating that 25% of cases of bladder cancer are not associated with hematuria. The reference actually states that as many as 25% of patients with bladder cancer may not have hematuria as their initial clinical manifestation [1]. Such patients have other signs and symptoms of tumor invasion that lead to diagnostic cystoscopy, and nearly all patients with bladder cancer develop hematuria or abnormal urine cytologic findings during their illness.
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Sneller MC, Walther MM, Talar-Williams C. Cyclophosphamide-Induced Bladder Cancer. Ann Intern Med. 1997;126:86. doi: 10.7326/0003-4819-126-1-199701010-00015

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Published: Ann Intern Med. 1997;126(1):86.

DOI: 10.7326/0003-4819-126-1-199701010-00015

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