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Letters |15 May 1997

Gram-Positive Infections and Quinolones in Neutropenia

Javier Altclas, MD; Patricia Costantini, MD; Miguel Dictar, MD

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  • Instituto de Criopreservacion y Transplante de Medula Osea IMA, Buenos Aires, Argentina Instituto de Oncologi Angel Roffo, Buenos Aires, Argentina Instituto de Alexander Fleming, Buenos Aires, Argentina
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TO THE EDITOR:
We read with interest the recent article by Bow and colleagues [1] on quinolone prophylaxis. The authors showed that the patients who received ofloxacin plus rifampin had fewer documented infections than patients who received other prophylactic regimens. However, these results were hampered by an increased rate of fevers of unknown origin. The authors also noted a high rate of yeast colonization (71%) in their patients. Only 6 of 31 patients were colonized by gram-negative rods; data on the susceptibility of these organisms are not available. The rate of febrile neutropenia and mortality were similar among the three groups.
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Altclas J, Costantini P, Dictar M. Gram-Positive Infections and Quinolones in Neutropenia. Ann Intern Med. ;126:830. doi: 10.7326/0003-4819-126-10-199705150-00026

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Published: Ann Intern Med. 1997;126(10):830.

DOI: 10.7326/0003-4819-126-10-199705150-00026

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