K. Sue Robinson, MD; David R. Anderson, MD; Michael Gross, MD; David Petrie, MD; Ross Leighton, MD; William Stanish, MD; David Alexander, MD; Michael Mitchell, MD; Bruce Flemming, MD; Michael Gent, DSc
The clinical significance of asymptomatic deep venous thrombosis that develops after joint arthroplasty and the value of screening tests to detect thrombi are uncertain.
To determine 1) the rate of symptomatic deep venous thrombosis or pulmonary embolism occurring after hospitalization for joint arthroplasty and 2) the value of screening compression ultrasonography.
Double-blind, randomized, controlled trial.
Tertiary care hospital.
1024 patients undergoing elective total hip or knee arthroplasty who received warfarin prophylaxis.
Patients were randomly assigned to undergo either bilateral compression ultrasonography or a sham procedure before hospital discharge. Patients with a diagnosis of asymptomatic deep venous thrombosis were treated after discharge with standard anticoagulant therapy; other patients had warfarin therapy discontinued at discharge. All patients were followed for 90 days.
In the screening group, asymptomatic proximal deep venous thrombosis was detected in 13 of 518 patients (2.5%). Another 4 patients subsequently developed symptomatic proximal deep venous thrombosis, and 1 patient treated for asymptomatic deep venous thrombosis developed major bleeding, for a total outcome event rate of 1.0% (5 of 518 patients). In the placebo group, 3 patients developed symptomatic proximal deep venous thrombosis and 2 had nonfatal pulmonary embolism, for a total event rate of 1.0% (5 of 506 patients) (difference, 0 percentage points [95% CI, −1.2 to 1.2 percentage points]).
In patients undergoing total hip or knee arthroplasty, the use of warfarin prophylaxis during hospitalization results in a very low rate of symptomatic deep venous thrombosis or pulmonary embolism after hospital discharge. The use of screening compression ultrasonography at hospital discharge does not seem to be justified in this setting.
K. Sue Robinson, David R. Anderson, Michael Gross, David Petrie, Ross Leighton, William Stanish, et al. Ultrasonographic Screening before Hospital Discharge for Deep Venous Thrombosis after Arthroplasty: The Post-Arthroplasty Screening Study: A Randomized, Controlled Trial. Ann Intern Med. 1997;127:439–445. doi: 10.7326/0003-4819-127-6-199709150-00004
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Published: Ann Intern Med. 1997;127(6):439-445.
Hospital Medicine, Venous Thromboembolism.
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