Robert S. Raymond, MD; Michael B. Fallon, MD; Gary A. Abrams, MD
Hepatitis C is an important cause of chronic liver disease. It is claimed that Complete Thymic Formula, an over-the-counter herbal dietary supplement, is beneficial for patients with hepatitis C.
To evaluate the efficacy and safety of Complete Thymic Formula.
Randomized, double-blind, placebo-controlled trial.
Tertiary referral center.
38 patients with hepatitis C who did not respond to or were intolerant of interferon therapy.
Complete Thymic Formula for 3 to 6 months or placebo for 3 months.
Serial measurements of hepatitis C virus (HCV) RNA titers.
No differences were noted at 3 months between the placebo group (n = 13) and the treatment group (n = 19) in mean HCV RNA titers (4.06 ± 1.52 × 106 copies/mL compared with 3.48 ± 1.92 × 106 copies/mL; P > 0.2). The 19 patients who completed 6 months of treatment with Complete Thymic Formula remained positive for HCV, and their mean HCV RNA titers were similar at 6 months and at baseline (2.78 ± 1.96 × 106 copies/mL compared with 3.12 ± 1.94 × 106 copies/mL; P > 0.2).
Complete Thymic Formula did not benefit patients who had previously received interferon therapy. Patients should be advised about use of this over-the-counter compound.
Raymond RS, Fallon MB, Abrams GA. Oral Thymic Extract for Chronic Hepatitis C in Patients Previously Treated with Interferon: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 1998;129:797–800. doi: 10.7326/0003-4819-129-10-199811150-00009
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Published: Ann Intern Med. 1998;129(10):797-800.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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