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Letters |6 November 2001

Fenfluramine and Phentermine

Diane Howlin, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Chelsea Village Internal Medicine; Chelsea, MI 48118 (Howlin)
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TO THE EDITOR:
The editorial by St. John Sutton on the diet medications fenfluramine and phentermine (1) contains two important factual errors. The author states that fenfluramine was introduced in 1959, when in fact phentermine was introduced in 1959. This is important because of the long safety record established for phentermine. Fenfluramine was introduced in 1973.
In the third paragraph, the author states, “Treatment of obesity with fenfluramine–phentermine was abruptly halted in 1997, when both agents were voluntarily withdrawn from the market by the manufacturer.” Phentermine is still readily available on the market under several trade names, including Adipex-P (GATE Pharmaceuticals, North Wales, Pennsylvania) and Ionamin (Medeva, Rochester, New York). I find it an important adjunct clinical tool in the treatment of obesity and note that no valvulopathies have been associated with its sole use.
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Howlin D. Fenfluramine and Phentermine. Ann Intern Med. 2001;135:840–841. doi: 10.7326/0003-4819-135-9-200111060-00018

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Published: Ann Intern Med. 2001;135(9):840-841.

DOI: 10.7326/0003-4819-135-9-200111060-00018

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2001 American College of Physicians
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