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Letters |17 December 2002

The Risk–Benefit Profile of Commonly Used Herbal Therapies

Sanford H. Levy, MD

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Author, Article, and Disclosure Information
  • State University of New York at Buffalo School of Medicine; Buffalo, NY 14221
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TO THE EDITOR:
I commend Edzard Ernst on an excellent comprehensive review of several popular herbs (1). However, I noticed that he did not mention a relatively recent randomized, controlled trial of St. John's wort in 200 outpatients with severe depression (baseline Hamilton Depression Scale score ≥ 20), which concluded that the herb was no more effective than placebo (2). In my opinion, the negative results of this large, multicenter, rigorous trial call into question the positive findings of all meta-analyses and systematic reviews showing benefit from St. John's wort in patients with depression.
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Levy SH. The Risk–Benefit Profile of Commonly Used Herbal Therapies. Ann Intern Med. ;137:1008. doi: 10.7326/0003-4819-137-12-200212170-00023

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Published: Ann Intern Med. 2002;137(12):1008.

DOI: 10.7326/0003-4819-137-12-200212170-00023

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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