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Letters |15 March 2005

Breast Cancer after Childhood Cancer

Lisa B. Kenney, MD, MPH

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  • From Dana-Farber Cancer Institute, Boston, MA 02115.
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IN RESPONSE:
One of the objectives of our study was to investigate how hormonal and reproductive factors, known to modify breast cancer risk in the general population, modify secondary breast cancer risk in the unique population of childhood cancer survivors. We acknowledge that breast carcinogenesis is complex and that ovarian steroid hormones are not the only factors that contribute to an individual's breast cancer risk. However, in our attempt to identify risk factors for secondary breast cancer beyond radiation treatment, we chose to focus on hormonal and reproductive factors that are well established as breast cancer risk factors for the general population (1). In addition, our analysis was limited to data that were available on this cohort. Future studies on secondary breast cancer risk in childhood cancer survivors might address the potential risk factors that Dr. Rossi and Mr. Howard mention.
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Kenney LB. Breast Cancer after Childhood Cancer. Ann Intern Med. ;142:472. doi: 10.7326/0003-4819-142-6-200503150-00017

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Published: Ann Intern Med. 2005;142(6):472.

DOI: 10.7326/0003-4819-142-6-200503150-00017

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2005 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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