Skip Navigation
Menu
Letters |16 August 2005

Subungual Splinter Hemorrhages: A Clinical Window to Inhibition of Vascular Endothelial Growth Factor Receptors?

Caroline Robert, MD, PhD; Sandrine Faivre; Eric Raymond; Jean-Pierre Armand; Bernard Escudier

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Institute Gustave Roussy, 94800 Villejuif Cedex, France.

    Potential Financial Conflicts of Interest: None disclosed.

×
FULL TEXT
TO THE EDITOR:
Background: Over the past few years, cancer therapy has been profoundly changed by the development of drugs targeting specific kinases involved in the proliferation of tumor or endothelial cells. Some kinase inhibitors exhibit antiangiogenic activity by targeting vascular endothelial growth factor receptors (VEGFRs).
Objective: We report the results of tests of 2 such inhibitors: SU11248 (Pfizer, New York, New York), which inhibits VEGFR-2, platelet-derived growth factor receptor (PDGFR), KIT, and flt3, and BAY 439006 (Onyx Pharmaceuticals, Emeryville, California, and Bayer, Leverkusen, Germany), which targets VEGFR-2 and VEGFR-3, PDGFR, and RAF gene products.
FULL TEXT
PDF
Not Available
Citations
Citation

Robert C, Faivre S, Raymond E, Armand J, Escudier B. Subungual Splinter Hemorrhages: A Clinical Window to Inhibition of Vascular Endothelial Growth Factor Receptors?. Ann Intern Med. 2005;143:313–314. doi: 10.7326/0003-4819-143-4-200508160-00021

Download citation file:

© 2018

×
Permissions

Published: Ann Intern Med. 2005;143(4):313-314.

DOI: 10.7326/0003-4819-143-4-200508160-00021

©
2005 American College of Physicians
48 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2018 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×