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Letters |16 August 2005

Subungual Splinter Hemorrhages: A Clinical Window to Inhibition of Vascular Endothelial Growth Factor Receptors?

Caroline Robert, MD, PhD; Sandrine Faivre; Eric Raymond; Jean-Pierre Armand; Bernard Escudier

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Institute Gustave Roussy, 94800 Villejuif Cedex, France.

    Potential Financial Conflicts of Interest: None disclosed.

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TO THE EDITOR:
Background: Over the past few years, cancer therapy has been profoundly changed by the development of drugs targeting specific kinases involved in the proliferation of tumor or endothelial cells. Some kinase inhibitors exhibit antiangiogenic activity by targeting vascular endothelial growth factor receptors (VEGFRs).
Objective: We report the results of tests of 2 such inhibitors: SU11248 (Pfizer, New York, New York), which inhibits VEGFR-2, platelet-derived growth factor receptor (PDGFR), KIT, and flt3, and BAY 439006 (Onyx Pharmaceuticals, Emeryville, California, and Bayer, Leverkusen, Germany), which targets VEGFR-2 and VEGFR-3, PDGFR, and RAF gene products.
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Robert C, Faivre S, Raymond E, Armand J, Escudier B. Subungual Splinter Hemorrhages: A Clinical Window to Inhibition of Vascular Endothelial Growth Factor Receptors?. Ann Intern Med. ;143:313–314. doi: 10.7326/0003-4819-143-4-200508160-00021

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Published: Ann Intern Med. 2005;143(4):313-314.

DOI: 10.7326/0003-4819-143-4-200508160-00021

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2005 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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