Anna Wald, MD, MPH; Andria G.M. Langenberg, MD; Elizabeth Krantz, MS; John M. Douglas Jr, MD; H. Hunter Handsfield, MD; Richard P. DiCarlo, MD; Adaora A. Adimora, MD, MPH; Allen E. Izu, MD; Rhoda Ashley Morrow, PhD; Lawrence Corey, MD
Note: This paper was presented in part at the 2002 National STD Prevention Conference, San Diego, California, 4–7 March 2002.
Grant Support: In part by National Institutes of Health Herpes Program Project Grant AI-30731 and Centers for Disease Control and Prevention Prevention Research Initiative UR6/CCU017828-02.
Potential Financial Conflicts of Interest: Employment: A.G.M. Langenberg (Chiron Corp., Corgentech, Inc.), A.E. Izu (Chiron Corp.); Stock ownership or options (other than mutual funds): A.G.M. Langenberg (Chiron Corp.), A.E. Izu (Chiron Corp.); Grants received: R.A. Morrow (Chiron Corp.), L. Corey (Chiron Corp.).
Requests for Single Reprints: Anna Wald, MD, MPH, University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Wald and Ms. Krantz: University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122.
Dr. Langenberg: Corgentec, Inc., 650 Gateway Boulevard, South San Francisco, CA 94080.
Dr. Douglas: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.
Dr. Handsfield: University of Washington, 325 Ninth Avenue, Seattle, WA 98104.
Dr. DiCarlo: Louisiana University School of Medicine, 2020 Gravier Street, Suite 102, New Orleans, LA 70012.
Dr. Adimora: Division of Infectious Disease, University of North Carolina School of Medicine, CB 7030, Chapel Hill, NC 27599.
Dr. Izu: Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608.
Dr. Morrow: University of Washington, Box 359300-W8814, Seattle, WA 98195.
Dr. Corey: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109.
Author Contributions: Conception and design: A. Wald, A.G.M. Langenberg, A.E. Izu, L. Corey.
Analysis and interpretation of the data: A. Wald, E. Krantz, A.E. Izu, L. Corey.
Drafting of the article: A. Wald, E. Krantz.
Critical revision of the article for important intellectual content: A. Wald, A.G.M. Langenberg, J.M. Douglas Jr, R.P. DiCarlo, R.A. Morrow, L. Corey.
Final approval of the article: A. Wald, A.G.M. Langenberg, E. Krantz, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow, L. Corey.
Provision of study materials or patients: J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora.
Statistical expertise: E. Krantz.
Obtaining of funding: A. Wald, L. Corey.
Administrative, technical, or logistical support: A. Wald, R.A. Morrow, L. Corey.
Collection and assembly of data: A.G.M. Langenberg, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow.
Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition.
To assess the relationship between condom use and acquisition of HSV-2 and HSV-1 among men and women.
Analysis of data collected as part of a clinical trial of an ineffective candidate vaccine for HSV-2.
Sexually transmitted disease clinics.
Men and women at risk for HSV-2 acquisition, defined as having 4 or more sexual partners or having a sexually transmitted disease in the past year.
Acquisition of HSV-2 and HSV-1 as measured by viral culture or change to positive HSV serostatus.
Of 1843 participants, 118 (6.4%) became infected with HSV-2. In multivariate analyses, participants reporting more frequent use of condoms were at lower risk for acquiring HSV-2 than participants who used condoms less frequently (hazard ratio, 0.74 [95% CI, 0.59 to 0.95]); categories of increasing condom use were 0% to 25%, 25% to 75%, and greater than 75% of sexual acts. Nineteen (2.9%) of 659 participants at risk for infection with HSV-1 became infected. No statistically significant association between condom use and infection with HSV-1 was found (hazard ratio, 0.79 [CI, 0.48 to 1.31]).
Use of condoms was measured by self-report, and persons who used condoms may have differed from those who did not.
Consistent use of condoms is associated with lower rates of infection with HSV-2 and should be routinely recommended.
Anna Wald, Andria G.M. Langenberg, Elizabeth Krantz, John M. Douglas, H. Hunter Handsfield, Richard P. DiCarlo, et al. The Relationship between Condom Use and Herpes Simplex Virus Acquisition. Ann Intern Med. 2005;143:707–713. doi: 10.7326/0003-4819-143-10-200511150-00007
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Published: Ann Intern Med. 2005;143(10):707-713.
Infectious Disease, Prevention/Screening, Sexually Transmitted Infections, Vaccines/Immunization.
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