Anna Peeters, PhD
In older men, do measures of adiposity and muscle mass predict mortality?
Prospective cohort study with mean follow-up of 6 years.
General practices in 24 towns in the United Kingdom.
4107 men 60 to 79 years of age who returned for the 20-year reexamination of the British Regional Heart Study. Men with heart failure were excluded.
Body mass index (BMI), measures of adiposity (waist circumference, waist-to-hip ratio, and fat mass), and measures of muscle mass (fat-free mass and midarm muscle circumference [MAMC, calculated as mid-upper arm circumference − 0.3142 × triceps skinfold thickness]).
All-cause mortality identified through linkage with National Health Service registers.
BMI had a reversed J-shaped association with mortality (Table). Relative to men with normal BMI (18.5 to 24.9 kg/m2), the 24 underweight men had a high mortality rate and were excluded from the other analyses. Mortality was not increased in overweight and obese men. Of the other measures considered individually, MAMC was the only one that predicted mortality (Table). However, after adjustment for MAMC, mortality risk increased with increasing waist circumference and waist-to-hip ratio (Table).
In older men, the combination of midarm muscle circumference and waist circumference best predicted mortality.
Association between measures of adiposity and muscle mass and all-cause mortality in older men at mean 6 years
*CI defined in Glossary. Relative risks adjusted for age, social class, physical activity, alcohol intake, and smoking. Relative risks for waist circumference and waist-to-hip ratio also adjusted for midarm muscle circumference.
Peeters A. The combination of low midarm muscle circumference and high waist circumference predicted higher mortality in older men. Ann Intern Med. 2008;148:JC3–11. doi: 10.7326/0003-4819-148-10-200805200-02011
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Published: Ann Intern Med. 2008;148(10):JC3-11.
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