David Burke, BMed, MRCPsych
In older adults with mild cognitive impairment (MCI), what is the long-term rate of conversion to dementia?
Included studies examined the progression of MCI, defined according to accepted criteria. Outcomes were dementia or probable Alzheimer disease.
MEDLINE, EMBASE/Excerpta Medica, and PsycINFO (to Mar 2008) were searched for cohort studies with ≥ 5 years of follow-up. 15 studies (n = 2404, mean age 62 to 82 y) met the selection criteria. Mean follow-up was 6 years (range 5 to 10 y).
The cumulative conversion rate to dementia was 31% (15 studies) and to Alzheimer disease was 33% (11 studies). The Table shows annual conversion rates. Annual conversion rates were lower in studies with longer duration of follow-up.
In older adults with mild cognitive impairment who were followed for ≤ 10 years, the annual conversion rate to dementia was 3.3%.
Progression from mild cognitive impairment to dementia in older adults*
*CI defined in Glossary.
Burke D. Review: Long-term annual conversion rate to dementia was 3.3% in older adults with mild cognitive impairment. Ann Intern Med. ;150:JC4–13. doi: 10.7326/0003-4819-150-8-200904210-02013
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Published: Ann Intern Med. 2009;150(8):JC4-13.
Dementia, Geriatric Medicine, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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