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Letters |2 February 2010

Reclassification Calculations for Persons With Incomplete Follow-up

Nancy R. Cook, ScD; Paul M. Ridker, MD

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Potential Conflicts of Interest: None disclosed.
  • From Brigham and Women's Hospital, Boston, MA 02215.
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Potential Conflicts of Interest: None disclosed.
IN RESPONSE:
We thank Drs. Steyerberg and Pencina for bringing up an important point about evaluating reclassification measures in the presence of survival data. When the outcome is time to an event, such as a cardiovascular event, care must be taken to accommodate censoring. The reclassification calibration statistic can easily be calculated by using survival data, as indicated in our article. The Kaplan–Meier estimate of the event rate as of 10 years, for example, can be used to obtain the expected number of events within each cell of the reclassification table. D'Agostino and Nam (1) suggest that with survival data, the degrees of freedom should be k − 1 rather than k − 2, where k in the setting of reclassification is the number of cells containing at least 20 persons.
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Cook NR, Ridker PM. Reclassification Calculations for Persons With Incomplete Follow-up. Ann Intern Med. 2010;152:196–197. doi: 10.7326/0003-4819-152-3-201002020-00020

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Published: Ann Intern Med. 2010;152(3):196-197.

DOI: 10.7326/0003-4819-152-3-201002020-00020

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