John-Michael Gamble, BScPharm, MSc; Sumit R. Majumdar, MD, MPH
Does use of statins increase risk for diabetes?
Included studies compared a statin with placebo or standard care for prevention of cardiovascular events in stable adults without diabetes. Outcome was incident diabetes.
MEDLINE, EMBASE/Excerpta Medica, and Cochrane Central Register of Controlled Trials (to Jan 2009) were searched for randomized controlled trials (RCTs) that had > 1000 participants, > 1 year of follow-up, and similar follow-up methods in both groups, and were published in English between 1994 and 2009. Trials that enrolled patients who had organ transplants or were receiving hemodialysis, and those reporting only changes in surrogate markers were excluded. 13 RCTs (n = 91 140, mean age 55 to 76 y) met the selection criteria. Overall mean duration of follow-up was 4 years (range of means 1.9 to 6.0 y). Authors of the original trials were contacted for numbers of patients without diabetes at baseline and cases of incident diabetes, if this information was not available in the published reports.
The overall incidence of diabetes was 12.23 cases/1000 patient-years in the statin group and 11.25 cases/1000 patient-years in the control group. Risk for diabetes was increased by 9% with statin use (Table).
Statin use increases risk for diabetes.
Statins vs placebo or standard care (control) and incidence of diabetes*
*Abbreviations defined in Glossary. RRI, NNH, and CI calculated from data in article using a random-effects model.
Gamble J, Majumdar SR. Review: Statin use increases risk for diabetes. Ann Intern Med. ;152:JC6–7. doi: 10.7326/0003-4819-152-12-201006150-02007
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Published: Ann Intern Med. 2010;152(12):JC6-7.
Cardiology, Coronary Risk Factors, Diabetes, Dyslipidemia, Endocrine and Metabolism.
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