Harvey J. Murff, MD, MPH
Does colorectal cancer screening with fecal immunochemical testing have higher patient adherence than screening with guaiac-based fecal occult blood testing (FOBT)?
Randomized controlled trial. ClinicalTrials.gov NCT00692211.
Within 90 days of agreeing to participate in study.
Primary care clinics and laboratory at a Veterans Affairs (VA) medical center and 5 community-based VA outpatient clinics in New Mexico.
404 primary care patients 50 to 80 years of age (mean age 64 y, 97% men) who were due for colorectal cancer screening and responded to a mailed invitation. Exclusion criteria were previous adenomatous polyps, colorectal cancer, or inflammatory bowel disease.
Fecal immunochemical (n = 202) or guaiac-based FOBT (n = 202) kits mailed to patients’ homes. Participants allocated to fecal immunochemical testing received OC-Auto FIT (Polymedco Inc., New York), which required 2 stool samples and had no dietary or medication restrictions. Participants allocated to guaiac-based FOBT received Hemoccult II test cards (Beckman Coulter, California), which required 3 stool samples and avoidance of nonsteroidal antiinflammatory drugs, vitamin C, rare meat, and foods containing peroxidase during the collection period.
Adherence (test completion within 90 d of agreement to participate in study).
Adherence was higher in patients allocated to fecal immunochemical testing than in those allocated to guaiac-based FOBT (Table).
Colorectal cancer screening with fecal immunochemical testing had higher patient adherence than screening with guaiac-based fecal occult blood testing.
Fecal immunochemical testing (FIT) vs guaiac-based fecal occult blood testing (gFOBT) for colorectal cancer screening‡
‡Abbreviations defined in Glossary. RBI, NNT, and CI calculated from control event rate and odds ratio in article; analysis adjusted for age, sex, race/ethnicity, clinic site, previous gFOBT, and comorbid conditions.
Murff HJ. Colorectal cancer screening with fecal immunochemical testing had higher adherence than screening with guaiac-based FOBT. Ann Intern Med. ;153:JC4–5. doi: 10.7326/0003-4819-153-8-201010190-02005
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Published: Ann Intern Med. 2010;153(8):JC4-5.
Cancer Screening/Prevention, Colorectal Cancer, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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