Sara Vazquez, PharmD; Matthew T. Rondina, MD
In patients hospitalized for conditions other than stroke, do graduated compression stockings (GCSs) prevent deep venous thrombosis (DVT)?
Included studies compared GCSs with no GCSs, with or without a background of another prophylaxis method, in patients hospitalized for conditions other than stroke. Outcomes included DVT and pulmonary embolism (PE).
Cochrane Peripheral Vascular Diseases Group Specialised Register (Jan 2010), Cochrane Central Register of Controlled Trials (Issue 4, 2009), and reference lists were searched for randomized controlled trials (RCTs). 18 RCTs (1463 patients, 2527 units of analysis) met the selection criteria. 6 trials randomized legs, such that each patient had 1 leg treated with GCSs and 1 control leg; in these studies, legs were the unit of analysis. 17 trials included surgery patients (52% of patients had general surgery). GCSs were applied the day before or the day of surgery and worn for 14 days or until discharge or full mobility. 17 trials used thigh-length GCSs; 1 trial included both thigh- and knee-length GCSs. In the 10 trials with a background of another prophylactic method, patients received Dextran 70 (3 trials), subcutaneous heparin (3 trials), aspirin (2 trials), low-molecular-weight heparin (1 trial), or sequential compression (1 trial). 8 studies described adequate randomization sequence generation, and 5 described adequate allocation concealment.
Meta-analysis showed that GCSs reduced risk for DVT, both with and without a background of another prophylaxis method (Table). Trials had low power for detecting the effects for PE.
In patients hospitalized for conditions other than stroke, graduated compression stockings reduce risk for deep venous thrombosis.
Graduated compression stockings (GCSs) vs control in patients hospitalized for conditions other than stroke*
*Abbreviations defined in Glossary. RRR, NNT, and CI calculated from risk ratios and risk differences in article.
†n = unit of analysis (patient or individual leg).
Vazquez S, Rondina MT. Review: Graduated compression stockings reduce deep venous thrombosis in hospitalized patients. Ann Intern Med. ;153:JC6–6. doi: 10.7326/0003-4819-153-12-201012210-02006
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Published: Ann Intern Med. 2010;153(12):JC6-6.
Hospital Medicine, Venous Thromboembolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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