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This monograph presents a morphologic and experimental study, combined with a critical review of the literature, of the involution of the ductus arteriosus. Multiple hypotheses and theories have been proposed to explain the closure of the patent ductus. The early theories tried to explain this process as purely passive in nature. Experimental work carried out in fetuses (1940-1950) led to the conclusions that an active process underlies the closure of the ductus, that closure takes place after birth, and that it is followed by involution of the ductus. The authors of this monograph question the reliability of the data obtained
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Involution of the Ductus Arteriosus: A Morphological and Experimental Study, with a Critical Review of the Literature.. Ann Intern Med. 1961;54:594–595. doi: 10.7326/0003-4819-54-3-594
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Published: Ann Intern Med. 1961;54(3):594-595.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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