S. Brunjes, M.D.; J. E. Hodgman, M.D.; J. Nowack, M.D.; V. J. Johns, M.D., F.A.C.P.
Brunjes S, Hodgman JE, Nowack J, Johns VJ. An Adrenal Medullary Function Test.. Ann Intern Med. 1961;54:1043. doi: 10.7326/0003-4819-54-5-1043_2
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Published: Ann Intern Med. 1961;54(5):1043.
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Although the adrenal medulla is not an essential organ, it is well known that it plays a role in the regulation of blood sugar through the effect of epinephrine on glycogenolysis. At the present time, adrenal medullary insufficiency is just emerging as a recognized syndrome.
In 1959, Broberger, Jungner, and Zetterstrom reported several children with "idiopathic spontaneous hypoglycemia of infancy" (McQuarrie's syndrome) whose epinephrine secretion failed to increase after insulin-induced hypoglycemia. They postulated that the cause of the spontaneous fasting hypoglycemia was a failure of the adrenal medulla to increase secretion of epinephrine during hypoglycemia.
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Adrenal Disorders, Endocrine and Metabolism.
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