P. R. Holt, M.D.; A. S. Cohen, M.D.; K. J. Isselbacher, M.D.
Holt PR, Cohen AS, Isselbacher KJ. Newer Concepts of Whipple's Disease.. Ann Intern Med. 1961;54:1049. doi: 10.7326/0003-4819-54-5-1049_1
Download citation file:
Published: Ann Intern Med. 1961;54(5):1049.
This content is PDF only. Please click on the PDF icon to access.
Whipple's disease was described and originally considered as an intestinal lipodystrophy. Peroral jejunal biopsy and early exploratory laparatomy have led to a more frequent diagnosis during life, and it has become apparent that the disease is systemic with pathologic involvement of lymph nodes, heart, lungs, and other organs. These tissues show a characteristic infiltration by macrophages filled with periodic acid-Schiff staining inclusions which have now been studied in the electron microscope and which reveal a very striking appearance associated with dense virus-like particles. The significance of these findings will be discussed.
It is of importance that while malabsorption is a
Learn more about subscription options.
Register Now for a free account.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Infectious Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only