Stephan Imfeld, MD
Potential Conflicts of Interest: None disclosed.
Imfeld S.; Comparative Effectiveness of Digital Versus Film-Screen Mammography. Ann Intern Med. 2012;156:250. doi: 10.7326/0003-4819-156-3-201202070-00022
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Published: Ann Intern Med. 2012;156(3):250.
TO THE EDITOR:
I read with interest the recent study by Kerlikowske and colleagues (1), who compared the accuracy of digital mammography with that of film-screen mammography in a large, population-based cohort of community-based imaging facilities.
The overall statistics of the main results show a small but statistically significant difference in specificity (0.6%; P < 0.001) and no statistical difference in sensitivity (P = 0.21). Nevertheless, the main focus, as described in the abstract, is a subgroup analysis of the latter, comparing sensitivity for different estrogen-receptor status and age strata without any statistical adjustment for multiple testing.
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