F. A. ZANTVOORT; F. H. M. DERKX; F. BOOMSMA; P. J. ROOS; M. A. D. H. SCHALEKAMP
To the editor: In the June issue Kearny and coworkers (1) describe a patient with severe hypokalemia who had plasma theophylline levels far in the toxic range. Their animal model also showed a significant fall in plasma potassium levels at theophylline levels above 40 mg/L. We, however, have observed that theophylline at plasma levels within the therapeutic range of 10 to 20 mg/L can cause a significant drop in plasma potassium levels in humans.
Theophylline, 6 to 7 mg/kg body weight, was given intravenously in 20 minutes to seven patients with chronic obstructive pulmonary disease. They had not used theophylline
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ZANTVOORT FA, DERKX FHM, BOOMSMA F, ROOS PJ, SCHALEKAMP MADH. Theophylline and Serum Electrolytes. Ann Intern Med. 1986;104:134–135. doi: 10.7326/0003-4819-104-1-134_2
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Published: Ann Intern Med. 1986;104(1):134-135.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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