Nathalie Morel, MD; Aude Rigolet, MD; Nicolas Schleinitz, MD, PhD; Alice Garnier, MD
Potential Conflicts of Interest: None disclosed.
Morel N., Rigolet A., Schleinitz N., Garnier A.; Bilateral Enlargement of the Lacrimal Glands From IgG4-Related Systemic Disease. Ann Intern Med. 2012;156:669-670. doi: 10.7326/0003-4819-156-9-201205010-00020
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Published: Ann Intern Med. 2012;156(9):669-670.
This article has been corrected. The original version (PDF) is appended to this article as a supplement.
Background: Immunoglobulin G4–related systemic disease was first described in 2003. It is a chronic inflammatory disorder defined by the presence of tissue-infiltrating plasma cells bearing IgG4. The association with IgG4 is a relatively recent finding, and the condition has previously been described under numerous other names.
Objective: To increase awareness of this recently described disease to avoid unnecessary investigations and reduce the time to diagnosis.
Case Report: In January 2011, physicians referred a 22-year-old man to our center for lymphadenopathy and lacrimal gland enlargement. His medical history was unremarkable except for removal of a 3-cm submaxillary adenopathy for suspected lymphoma 4 years ago. The pathologic examination showed only nonspecific inflammation.
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