MARK DONOWITZ, M. D.; GRACE ELTA, M.D.; STEPHEN ROBERT BLOOM, M.D.; LARRY NATHANSON, M.D.
DONOWITZ M, ELTA G, BLOOM SR, NATHANSON L. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome in HLA-Identical Siblings. Ann Intern Med. 1980;93:283-284. doi: 10.7326/0003-4819-93-2-284
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Published: Ann Intern Med. 1980;93(2):283-284.
Thrombocytopenia, microangiopathic hemolytic anemia, and renal failure are features common to both hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura, with neurologic disturbances being more frequently observed in the latter disorder. The causes of these syndromes are unknown. Neither the occurrence of hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura in the same family nor tissue-typing using the HLA system in siblings with these disorders has been previously reported. The cases described below occurred 6½ years apart in HLA-identical brothers. Although features of these two cases appear sufficiently different to allow separation into thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, the unique occurrence in brothers
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Hematology/Oncology, Nephrology, Red Cell Disorders, Platelet Disorders, Coagulopathies.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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