ELLIS LADER, M.D.; LEE YANG, B.A.; ALLAN CLARKE, R. PH.
To the editor: A cause of warfarin antagonism is unappreciated inclusion of vitamin K analogues in commercial dietary supplements. The following case report is pertinent to this point.
A 60-year-old woman had undergone aortic-valve replacement surgery 15 years before admission and had been anticoagulated thereafter with sodium warfarin. Satisfactory anticoagulation has been maintained chronically with daily administration of 5 mg of warfarin. With institution of dietary supplementation with Osmolite (Ross Laboratories, Columbus, Ohio), up to 1200 mL (12 kcal) daily, the patient's prothrombin time fell to control levels within 1 week. Stepwise increments in her daily warfarin dose to 15
Learn more about subscription options.
Register Now for a free account.
LADER E, YANG L, CLARKE A. Warfarin Dosage and Vitamin K in Osmolite. Ann Intern Med. 1980;93:373–374. doi: 10.7326/0003-4819-93-2-373_3
Download citation file:
Published: Ann Intern Med. 1980;93(2):373-374.
Cardiology, Valvular Heart Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only