Anthony O'Regan, MD; Jeffrey S. Berman, MD
O'Regan A, Berman JS. Sarcoidosis. Ann Intern Med. 2012;156:ITC5-1. doi: 10.7326/0003-4819-156-9-201205010-01005
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Published: Ann Intern Med. 2012;156(9):ITC5-1.
Sarcoidosis is an idiopathic granulomatous disease. Although often considered a pulmonary disease, it can affect virtually any organ with diverse and protean manifestations. However, most patients present with typical symptoms that are recognizable at the first clinical encounter. Although the cause is incompletely understood, the pathogenesis of sarcoidosis involves antigen exposure in a genetically susceptible host resulting in typical granulomatous inflammation with a prominent Th1-cell–mediated immune response, which either resolves or progresses to organ fibrosis. The identity of the antigen or antigens and the exact genetics of predisposition remain areas of intense research. The clinical course of sarcoidosis ranges from an incidental finding to a devastating, life-threatening disease. No clinical parameters allow an accurate prediction of the clinical course of sarcoidosis, although certain manifestations, such as lung fibrosis, cutaneous disease, and neurologic disease, suggest chronicity. It is benign in most cases; however, mortality seems to be increasing in the United States and England, particularly in women. Most deaths are related to pulmonary or cardiac disease.
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Cardiology, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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