Richard J. Johnson, MD; Miguel A. Lanaspa, PhD; Carlos Roncal-Jimenez, BS; Laura G. Sanchez-Lozada, PhD
Laura G. Sanchez-Lozada, PhD
INC Ignacio Chavez
14080 Mexico City, Mexico
Potential Conflicts of Interest: Dr. Johnson: Board membership: Amway Scientific Board, Gatorade Museum Board; Consultancy: Ardea, Astellas, Danone, Novartis; Employment: University of Colorado, University of Florida; Expert testimony: expert on kidney diseases; Grants/grants pending (money to institution): Amway, Cardero, Danone, Questcor, Sugar Foundation; Payment for lectures including service on speakers bureaus: honoraria associated with lectures to universities or societies; Patents (planned, pending or issued): have patent applications on blocking fructose metabolism or lowering uric acid as a means for preventing or treating obesity and metabolic syndrome and patent issued on allopurinol for treatment of hypertension; Royalties: Elsevier; Stock/stock options: Cardero. Dr. Sanchez-Lozada: Grant (money to institution): CONACyT.
Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG. Effects of Excessive Fructose Intake on Health. Ann Intern Med. 2012;156:905. doi: 10.7326/0003-4819-156-12-201206190-00024
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Published: Ann Intern Med. 2012;156(12):905.
TO THE EDITOR:
The review by Sievenpiper and colleagues (1) has the great potential for being taken to mean that excessive intake of fructose is safe and does not promote long-term weight gain, which should be interpreted with great caution. For example, one would not expect to see a difference in weight gain for any food if both control and treatment contain the same number of calories. The way fructose increases weight gain is by altering appetite, such that it stimulates increased food intake, by inducing leptin resistance or by direct effects on the brain (2, 3). However, if food intake is forcefully kept equal, how can one expect any difference in weight gain between groups? On the other hand, the hypercaloric studies analyzed in this meta-analysis are flawed, because the median duration of the studies was only 1.5 weeks. How can anyone expect the effects of fructose on weight to manifest in such a short time? The problem is that obesity does not occur overnight—it takes years (4).
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