Arthur B. Chausmer, MD, PhD
Potential Conflicts of Interest: None disclosed.
Chausmer AB. Dose Response to Vitamin D Supplementation in Postmenopausal Women. Ann Intern Med. 2012;157:384. doi: 10.7326/0003-4819-157-5-201209040-00014
Download citation file:
Published: Ann Intern Med. 2012;157(5):384.
TO THE EDITOR:
I read the recent article by Gallagher and colleagues (1) with interest. Although it correctly stated that there was a relationship between the serum 25-hydroxyvitamin D (25-[OH]D) intermediate metabolite and the oral dose, there are some other important points to consider. It is important to note that, contrary to popular opinion, the level of circulating 25-(OH)D should not be considered an appropriate indicator of true vitamin D sufficiency or insufficiency. Because the total body load of any of the vitamin D metabolites has yet to be quantitatively assessed, there is no way of knowing whether there is a deficiency; what relationship, if any, exists between blood levels and total body storage; or what the relationship between active and inactive metabolites might be. These are key points that need to be addressed.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only