Janet A. Schlechte, MD
This article was published at www.annals.org on 11 April 2013.
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0273.
Requests for Single Reprints: Janet A. Schlechte, MD, E401-1 GH, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242; e-mail, firstname.lastname@example.org.
Author Contributions: Conception and design: J.A. Schlechte.
Drafting of the article: J.A. Schlechte.
Final approval of the article: J.A. Schlechte.
Schlechte JA. Update in Endocrinology: Evidence Published in 2012. Ann Intern Med. 2013;158:821-824. doi: 10.7326/0003-4819-158-11-201306040-00106
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Published: Ann Intern Med. 2013;158(11):821-824.
This article summarizes studies published in 2012 that will influence practice of endocrinology and diabetes. Studies were identified from among the highest-rated and most-accessed articles in ACP JournalWise. In diabetes, a large trial showed no adverse cardiovascular consequences of long-term insulin use and no effect of insulin on rates of cancer. A trial of metformin, rosiglitazone, and lifestyle intervention in obese youth with type 2 diabetes showed that treatment failed in half of the participants over approximately 4 years. In 2 randomized, controlled trials, glycemic control rapidly improved after bariatric surgery. In thyroid medicine, low- and high-dose radioiodine along with thyroid hormone withdrawal or recombinant human thyroid-stimulating hormone (TSH) were shown to be equally effective in managing low-risk thyroid cancer. A gene-expression test successfully distinguished benign from malignant samples of cytologically indeterminate thyroid nodules. In osteoporosis research, new data suggested that screening bone mineral density (BMD) can be done at approximately 15-year intervals in older women with normal BMD or mild osteopenia. A large meta-analysis analyzing vitamin D intake showed that high-dose vitamin D prevents fractures. Finally, in a randomized trial, the long-acting bisphosphonate zoledronic acid reduced vertebral fracture rates in men with osteoporosis.
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Endocrine and Metabolism, Updates, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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