Jeremy Sugarman, MD, MPH, MA
This article was published at www.annals.org on 13 August 2013.
Some of the ideas described in this article were presented at the International AIDS Society Symposium, “Toward an HIV Cure,” in Kuala Lumpur, Malaysia, on 30 June 2013.
Grant Support: In part by National Institute of Allergy and Infectious Diseases, National Institute of Drug Abuse, and National Institute of Mental Health under cooperative agreement UM1AI068619 to the HIV Prevention Trials Network, and the Johns Hopkins Center for AIDS Research, which is funded by the National Institutes of Health (grant 1P30AI094189).
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-1696.
Requests for Single Reprints: Jeremy Sugarman, MD, MPH, MA, Johns Hopkins Berman Institute of Bioethics, 1809 Ashland Avenue, Baltimore, MD 21205; e-mail, email@example.com.
Author Contributions: Conception and design: J. Sugarman.
Drafting of the article: J. Sugarman.
Critical revision of the article for important intellectual content: J. Sugarman.
Final approval of the article: J. Sugarman.
Sugarman J. HIV Cure Research: Expanding the Ethical Considerations. Ann Intern Med. 2013;159:490-491. doi: 10.7326/0003-4819-159-7-201310010-00694
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Published: Ann Intern Med. 2013;159(7):490-491.
Mounting evidence is fueling excitement over the possibility of curing HIV infection. Two “Boston patients” who had bone marrow transplantations (1) and a “Mississippi baby” who was given aggressive antiretroviral therapy (2) soon after birth seem to be free of HIV infection. These accounts add to earlier reports of the “Berlin patient” who lacks evidence of HIV infection after transplantation with cells conferring HIV resistance (3) and members of the Visconti cohort who appear to be free of HIV infection after stopping antiretroviral therapy (4). In aggregate, these findings support the plausibility of “HIV cure research” aimed at eliminating the need for continuous antiretroviral therapy, with its inherent burdens and costs.
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Infectious Disease, HIV, Ethics.
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