Marianthi Kiriakidou, MD
Kiriakidou M. Systemic Lupus Erythematosus. Ann Intern Med. 2013;159:ITC4-1. doi: 10.7326/0003-4819-159-7-201310010-01004
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Published: Ann Intern Med. 2013;159(7):ITC4-1.
Systemic lupus erythematosus (SLE, lupus) is a condition in which the immune system attacks healthy cells and tissues throughout the body. Immune system activation in SLE is characterized by exaggerated B-cell and T-cell responses and loss of immune tolerance against self antigens. Production and defective elimination of antibodies, circulation and tissue deposition of immune complexes, and complement and cytokine activation contribute to clinical manifestations that range from mild fatigue and joint pain to severe, life-threatening organ damage.
Because the symptoms of SLE vary widely and the condition often goes undiagnosed, it is unclear how many people in the United States have the disease. It is diagnosed 9 times more often in women than in men, which implies pathogenic mechanisms more prevalent in women. These mechanisms, which probably involve effects of sex chromosomes, specific genes, and hormones, have not been completely elucidated. SLE is more common and more severe in African American women, Hispanic women, and those of other ethnic minorities (1).
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Infectious Disease, Nephrology, Neurology, Rheumatology, CNS Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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