Dorit Samocha-Bonet, PhD; Antony D. Karelis, PhD; Rémi Rabasa-Lhoret, MD, PhD
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0023.
Samocha-Bonet D., Karelis A., Rabasa-Lhoret R.; Metabolically Healthy Overweight and Obesity. Ann Intern Med. 2014;160:513-514. doi: 10.7326/L14-5007-2
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Published: Ann Intern Med. 2014;160(7):513-514.
Kramer and colleagues’ (1) data suggest that metabolically healthy obese persons have increased cardiovascular and all-cause mortality risk compared with their normal-weight counterparts. However, the relative risk (RR) reported for the metabolically healthy obese group is approximately one half that reported for the metabolically unhealthy obese group (1.24 vs. 2.65, respectively). This finding suggests that metabolically healthy obese persons are relatively protected from some adverse outcomes of obesity.
Cross-sectional studies suggest that metabolic health in obesity is associated with “healthy” adipose tissue that is capable of storing fat away from insulin-sensitive tissues, primarily the liver (2, 3). Longitudinal studies with long-term follow-up are vital to determine whether a snapshot of metabolically healthy obesity is stable and whether it ultimately translates into decreased risk for cardiovascular disease, type 2 diabetes, cancer, and all-cause mortality at an older age.
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