Gerson T. Lesser, MD
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0025.
Lesser GT. Metabolically Healthy Overweight and Obesity. Ann Intern Med. 2014;160:514-515. doi: 10.7326/L14-5007-4
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Published: Ann Intern Med. 2014;160(7):514-515.
Kramer and colleagues (1) and Hill and Wyatt (2) suggest that healthy obesity is a myth. However, there are problems with the data and, more important, with the concepts. Two large studies (3, 4) included in Kramer and colleagues' review represent approximately 90% of participants followed for 10 years. Compared with metabolically healthy normal-weight participants, metabolically healthy obese participants in 1 study had a mortality rate just short of significance and in the other study had an RR of 1.00—hardly “strong evidence” (2).
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