Niels van der Hoeven, MD; Ieke Visser, MD; Aart Schene, MD, PhD; Bert-Jan van den Born, MD, PhD
Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0038.
van der Hoeven N, Visser I, Schene A, van den Born B. Severe Hypertension Related to Caffeinated Coffee and Tranylcypromine: A Case Report. Ann Intern Med. 2014;160:657-658. doi: 10.7326/L14-5009-8
Download citation file:
Published: Ann Intern Med. 2014;160(9):657-658.
Background: Hypertension can develop in patients receiving monoamine oxidase (MAO) inhibitors who consume tyramine-rich food, such as aged cheeses and some alcoholic beverages. Tyramine leads to increased norepinephrine release at adrenergic nerve terminals when MAO is inhibited (1, 2). In vitro studies show that caffeine inhibits MAO, suggesting that caffeine might supplement the effects of MAO inhibitors used to treat atypical depression and other disorders (3-5).
Objective: To report a case of severe hypertension related to an interaction between caffeine and MAO inhibitor therapy.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Nephrology, Hypertension, Coronary Risk Factors.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only