Miguel A. Martínez-González, MD, PhD; Ramón Estruch, MD, PhD; Dolores Corella, DPharm, PhD; Emilio Ros, MD, PhD; Jordi Salas-Salvadó, MD, PhD
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-1725.
Martínez-González M., Estruch R., Corella D., Ros E., Salas-Salvadó J.; Prevention of Diabetes With Mediterranean Diets. Ann Intern Med. 2014;161:157-158. doi: 10.7326/L14-5014-2
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Published: Ann Intern Med. 2014;161(2):157-158.
With regard to the potential “imbalances” in the baseline characteristics of participants in the PREDIMED (Prevención con Dieta Mediterránea) study and competing risk analyses, sex distribution was the only potentially relevant “imbalance” in our trial. The control group included a slightly higher proportion of women than the Mediterranean diet intervention groups. Female sex was associated with a lower risk for new-onset diabetes (age-adjusted hazard ratio [HR], 0.81 [95% CI, 0.63 to 1.04]) and cardiovascular events (age-adjusted HR, 0.45 [CI, 0.35 to 0.57]) in the overall cohort. It was also associated with a lower risk for cardiovascular disease among participants with diabetes (age-adjusted HR, 0.52 [CI, 0.39 to 0.70]).
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