William G. Kussmaul, III, MD; Ashwini R. Sehgal, MD
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-1630.
Requests for Single Reprints: William G. Kussmaul III, MD, Hahnemann University Hospital, 230 North Broad Street, Room 1536, South Tower, Philadelphia, PA 19102.
This article was published online first at www.annals.org on 12 August 2014.
Current Author Addresses: Dr. Kussmaul: Hahnemann University Hospital, 216 North Broad Street, Suite 201, Philadelphia, PA 19102.
Dr. Sehgal: Case Western Reserve University, 2500 MetroHealth Drive, Rammelkamp 213, Cleveland, OH 44109.
Kussmaul W., Sehgal A.; Clearing Up Cardiorenal Confusion. Ann Intern Med. 2014;161:528-529. doi: 10.7326/M14-1630
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Published: Ann Intern Med. 2014;161(7):528-529.
Timely diagnosis of cardiac injury is necessary to limit the extent of myocardial damage and to prevent and treat complications. Because cardiac injury involves disruption of myocytes, the diagnosis of acute myocardial infarction has relied on the measurement of released cellular components and the presence of symptoms and electrocardiographic abnormalities. Previously used markers, such as creatine kinase, myoglobin, and lactate dehydrogenase, are also present in some noncardiac tissues, which limits their sensitivity and specificity. In contrast, cardiac troponins (troponin I and troponin T) are proteins that regulate muscle contraction and are found almost exclusively in the heart. Therefore, they are the most useful biomarkers of cardiac injury currently available (1).
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Cardiology, Nephrology, Chronic Kidney Disease, Acute Coronary Syndromes, Coronary Heart Disease.
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