Mihoko Yoshino, MD, PhD; Samuel Klein, MD
Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-2820.
Requests for Single Reprints: Samuel Klein, MD, Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St. Louis, MO 63110; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Yoshino and Klein: Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St. Louis, MO 63110.
Yoshino M., Klein S.; Endurance Exercise: More Pain, More Metabolic Gain. Ann Intern Med. 2015;162:385-386. doi: 10.7326/M15-0059
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Published: Ann Intern Med. 2015;162(5):385-386.
Obesity is associated with a constellation of metabolic abnormalities, including insulin resistance, dyslipidemia, and excessive intrahepatic triglyceride content, which are important risk factors for type 2 diabetes and cardiovascular disease (1). Obese persons who have abdominal or upper-body obesity are at much higher risk for cardiometabolic diseases than those with lower-body, gluteal, or femoral obesity. Epidemiologic studies have consistently shown that waist circumference, which provides an index of abdominal fat mass, is a better predictor of whether a person will develop type 2 diabetes and coronary heart disease than body mass index (2).
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Cardiology, Endocrine and Metabolism, Diabetes, Obesity, Coronary Risk Factors.
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