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The full report is titled “Cost-Effectiveness and Population Impact of Statins for Primary Prevention in Adults Aged 75 Years or Older in the United States.” It is in the 21 April 2015 issue of Annals of Internal Medicine (volume 162, pages 533-541). The authors are M.C. Odden, M.J. Pletcher, P.G. Coxson, D. Thekkethala, D. Guzman, D. Heller, L. Goldman, and K. Bibbins-Domingo.
Statins for Primary Prevention in Older Adults. Ann Intern Med. 2015;162:I-28. doi: 10.7326/P15-9012
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Published: Ann Intern Med. 2015;162(8):I-28.
Many older adults who do not have heart disease take statins to prevent heart attacks and problems related to heart attacks.
Only a few small studies of statin use have been done in older adults, and the results have not yet confirmed the value of this practice.
People living in the United States who were aged 75 to 94 years.
The investigators used models to estimate the cost-effectiveness of statins compared with no statins.
Statins were found to effectively prevent heart attacks and related problems at an acceptable cost when the investigators excluded side effects of the drugs that might be more of a problem in elderly adults than in younger people. However, this was not the case when they included even small amounts of these side effects in their analyses.
This type of analysis requires many assumptions.
New clinical trials are required to understand whether older adults should take statins to prevent heart attacks and related problems.
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Cardiology, Geriatric Medicine, Dyslipidemia, Coronary Risk Factors, Prevention/Screening.
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